The Design of Interactive Visualizations and Analytics for Public Health Data

Public health data plays a critical role in ensuring the health of the populace. Professionals use data as they engage in efforts to improve and protect the health of communities. For the public, data influences their ability to make health-related decisions. Health literacy, which is the ability of an individual to access, understand, and apply health data, is a key determinant of health. At present, people seeking to use public health data are confronted with a myriad of challenges some of which relate to the nature and structure of the data. Interactive visualizations are a category of computational tools that can support individuals as they seek to use public health data. With interactive visualizations, individuals can access underlying data, change how data is represented, manipulate various visual elements, and in certain tools control and perform analytic tasks. That being said, currently, in public health, simple visualizations, which fail to effectively support the exploration of large sets of data, are predominantly used. The goal of this dissertation is to demonstrate the benefit of sophisticated interactive visualizations and analytics. As improperly designed visualizations can negatively impact users’ discourse with data, there is a need for frameworks to help designers think systematically about design issues. Furthermore, there is a need to demonstrate how such frameworks can be utilized. This dissertation includes a process by which designers can create health visualizations. Using this process, five novel visualizations were designed to facilitate making sense of public health data. Three studies were conducted with the visualizations. The first study explores how computational models can be used to make sense of the discourse of health on a social media platform. The second study investigates the use of instructional materials to improve visualization literacy. Visualization literacy is important because even when visualizations are designed properly, there still exists a gap between how a tool works and users’ perceptions of how the tool should work. The last study examines the efficacy of visualizations to improve health literacy. Overall then, this dissertation provides designers with a deeper understanding of how to systematically design health visualizations

Reflections From First Time Blended Programming Instructors - Teaching Challenges and Lessons Learned

Instructors charged with developing online courses to introduce computer programming concepts are confronted with a number of challenges relating to an evolving area of knowledge, creating an authentic online learning environment, and diverse background, values, and motivation of novice learners. Here we describe novice learners as individuals who have had little or no previous experience with programming and who do not intend to become professional programmers. Over the course of the last year we have designed an online programming course in JavaScript for novice learners. The goal of the course is to help people, with no programming background, realize that with a little practice and guidance, virtually anyone can write a computer program. In our session, the audience will be introduced to 3 major challenges we faced when developing the blended course and be given strategies that we used to overcome these obstacles. Because these strategies are based on pedagogy, they are applicable to the development of new online courses for all STEM disciplines

Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Please read abstract in the article.Cape Peninsula University of Technology and National Research Foundation (South Africa).https://www.elsevier.com/locate/ejpharhj2023Paraclinical Science

Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action

Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100 mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while Invivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.https://www.pjps.pk/homeam2023Paraclinical Science

The therapeutic potential of the novel angiotensin-converting enzyme 2 in the treatment of coronavirus disease-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic crises. Furthermore, COVID-19 can easily be transmitted regardless of religion, race, sex, or status. Globally, high hospitalization rates of COVID-19 patients have been reported, and billions of dollars have been spent to contain the pandemic. Angiotensin-converting enzyme (ACE) 2 is a receptor of SARS-CoV-2, which has a significant role in the entry of the virus into the host cell. ACE2 is highly expressed in the type II alveolar cells of the lungs, upper esophagus, stratified epithelial cells, and other tissues in the body. The diminished expressions of ACE2 have been associated with hypertension, arteriosclerosis, heart failure, chronic kidney disease, and immune system dysregulation. Overall, the potential drug candidates that could serve as ACE2 activators or enhance the expression of ACE2 in a disease state, such as COVID-19, hold considerable promise in mitigating the COVID-19 pandemic. This study reviews the therapeutic potential and pharmacological benefits of the novel ACE2 in the management of COVID-19 using search engines, such as Google, Scopus, PubMed, and PubMed Central.http://www.veterinaryworld.orgdm2022Paraclinical Science

Clofibrate, a peroxisome proliferator–activated receptor-alpha (PPARα) agonist, and Its molecular mechanisms of action against sodium fluoride–induced toxicity

AVAILABILITY OF DATA AND MATERIALS : Data will be made available based on request from the corresponding author.Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized for prevention of dental caries and tartar formation, and may be added to mouthwash, mouth rinse, and toothpastes. This study is aimed at mitigating fluoride-induced hypertension and nephrotoxicity with clofibrate, a peroxisome proliferator–activated receptor-alpha (PPARα) agonist. For this study, forty male Wistar rats were used and randomly grouped into ten rats per group, control, sodium fluoride (NaF; 300 ppm) only, NaF plus clofibrate (250 mg/kg) and NaF plus lisinopril (10 mg/kg), respectively, for 7 days. The administration of NaF was by drinking water ad libitum, while clofibrate and lisinopril were administered by oral gavage. Administration of NaF induced hypertension, and was accompanied with exaggerated oxidative stress; depletion of antioxidant defence system; reduced nitric oxide production; increased systolic, diastolic and mean arterial pressure; activation of angiotensin-converting enzyme activity and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); and testicular apoptosis. Treatment of rats with clofibrate reduced oxidative stress, improved antioxidant status, lowered high blood pressure through the inhibition of angiotensin-converting enzyme activity, mineralocorticoid receptor over-activation, and abrogated testicular apoptosis. Taken together, clofibrate could offer exceptional therapeutic benefit in mitigating toxicity associated with sodium fluoride.Cape Peninsula University of Technology and National Research Foundation (South Africa).https://link.springer.com/journal/12011hj2023Paraclinical Science

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Adapting lesson delivery to accommodate changing classroom sizes

Research indicates that class size may influence student achievement (Dillon et al., 2002). So how does one adapt the delivery of course content in larger classes so that student achievement is not negatively impacted? While some may advocate for smaller classes, university lecturers typically do not have control over the size of their classes. An alternative is to focus on increasing student motivation and creating a sense of community. In this presentation, I will present observations garnered from teaching an introductory programming class to three different class sizes (i.e., 50, 100, and 25 students). I will also discuss strategies that proved effective in creating a sense of community and motivating students. In this session, the audience will be shown how a shift from a primarily lecture-based format to an active learning style was implemented in the different classes. As a focus on learning instead of teaching has the potential to impact student achievement (Weimer, 2003) this research is of benefit to anyone confronted with changing class sizes. Innovative methods for measuring student motivation during the semester will also be discussed. Dillon et al. (2002). Retrieved from https://www.ilr.cornell.edu/sites/ilr.cornell.edu/files/WP28.pdf Weimer (2003). Change: The Magazine of Higher Learning, 35(5), 48–54

Lightweight strategies to improve classroom climate and promote wellness

Navigating college is not a trivial endeavor. During their years in university, students face a myriad of challenges, some of which can be characterized as “growing pains.” Their process of maturing is not separate from their academic experiences. Therefore, it is crucial that as we advocate for wellness, we emphasize strategies that explore the intersections of intellectual, social, and emotional development. In this session, I report on work done in an introductory computing course to alleviate stress, build community, and educate both students and teaching assistants about the critical role of mental health. The strategies presented are grounded in a framework by Ambrose et al. that highlights the role of tone, human interaction, anonymity, and ground rules in shaping the classroom climate (Ambrose, Lovett, Bridges, DiPietro, & Norman, 2010). As teaching authentically can positively impact the learning experience of students (Johnson & LaBelle, 2017) I will also present how Appreciative Inquiry (Whitney & Cooperrider, 2011) influenced the strategies utilized. Anecdotal evidence from course evaluations of the effectiveness of the strategies will also be discussed. A critical element of promoting wellness across large courses is ensuring that all course staff are actively engaged in wellness initiatives. At my institution, our first-year course has roughly 40 teaching assistants each term. In this presentation, I will also detail my experience in incorporating small changes into our weekly staff meetings to improve staff-student interactions. References Ambrose, S. A., Lovett, M., Bridges, M. W., DiPietro, M., & Norman, M. K. (2010). How learning works : seven research-based principles for smart teaching. Jossey-Bass. Johnson, Z. D., & LaBelle, S. (2017). An examination of teacher authenticity in the college classroom. Communication Education, 66(4), 423–439. Whitney, D. & Cooperrider, D. (2011). Appreciative inquiry: a positive revolution in change. ReadHowYouWant.com